Abstract
Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in foam cell formation and atherosclerosis. We studied LPS-mediated foam cell formation and the effect of resveratrol. Resveratrol pretreatment strongly suppressed LPS-induced foam cell formation. To determine if resveratrol affected the expression of genes that control ROS generation in macrophages, NADPH oxidase 1 (Nox1) was measured. Resveratrol treatment of macrophages inhibited LPS-induced Nox1 expression as well as ROS generation, and also suppressed LPS-induced MCP-1 mRNA and protein expression. We investigated the upstream targets of Nox1 and MCP-1 expression and found that Akt-forkhead transcription factors of the O class (FoxO3a) is an important signaling pathway that regulates both genes. These inhibitory effects of resveratrol on Nox1 expression and MCP-1 production may target to the Akt and FoxO3a signaling pathways.
Highlights
Resveratrol is a polyphenol existing in grapes, berries, and peanuts
Our results demonstrate that LPS is a potent inducer of NADPH oxidase 1 (Nox1) and monocyte chemotactic protein-1 (MCP-1) expression in mouse macrophages via an Akt and forkhead transcription factors of the O class (FoxO3a)-dependent signaling pathway, and that this pathway is inhibited by resveratrol
Resveratrol blocks LPS-induced foam cell formation We examined the influence of resveratrol in foam resveratrol
Summary
Resveratrol is a polyphenol existing in grapes, berries, and peanuts. Resveratrol protects plants from fungal infection; exhibits anti-oxidative, antiinflammatory, and chemopreventive properties in mammalian systems (Park et al, 2007); and inhibits macrophage activation (Pervaiz, 2003). Resveratrol has been proposed to contribute to anti-atherosclerotic properties (Hou et al, 2008). A number of studies using animal models support this suggestion (Zang et al, 2006). Mechanisms proposed to explain the anti-atherosclerotic properties of resveratrol include reduction of LDL oxidation, inhibition of monocyte chemotactic protein-1 (MCP-1) production (Cullen et al, 2007a), inhibition of macrophage inflammation, and control of plasma cholesterol levels. The precise mechanisms concerning the anti-atherosclerosis effects of resveratrol remain unclear
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
