Abstract
Background: Minimal Hepatic Encephalopathy (MHE) is characterized by an impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL). The aim of our study is evaluating the potential liver health promoting a perspective of Resveratrol (RV) activities and evaluate whether RV treatment may improve health related quality of life (HRQL) and reduce depression and anxiety in patients with MHE. Methods: We evaluated depression using the Beck Depression Inventory test, anxiety with State-trait anxiety inventory test, quality of life through SF-36 test, and ammonia serum levels in 70 MHE patients that were randomized into two groups. Results: In the comparison between RV group and placebo group we observed a decrease in Back Depression Inventory (BDI) (p < 0.001), in State-trait anxiety inventory (STAI) (p < 0.001), and improve in physical function (p < 0.001), in role physical (p < 0.05), in body pain (p < 0.05), in general health (p < 0.001), in vitality (p < 0.05), and in social function (p < 0.001). Conclusions: Resveratrol showed efficacy in the treatment of depression, anxiety, and ammonia serum levels, and improved the quality of life Of MHE patients.
Highlights
Minimal Hepatic Encephalopathy (MHE) is a frequent and common complication of cirrhosis, affecting nearly 80% of cirrhotic patients
Physical examination in MHE is often normal; patients may present subtle abnormalieties, interfering with executive function, including their working memory and orientation, impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL) [1]. This underrecognized and underdiagnosized syndrome often presents minimal changes in personality and in memory, intellectual function, concentration, and coordination. These disorders impinge on the health related quality of life and have a negative prognostic value in relation to the occurrence of both bouts of overt hepatic encephalopathy and death [2]
No significant differences were observed in biohumoral tests, at etiologic factors in cirrhosis (Table 1)
Summary
Minimal Hepatic Encephalopathy (MHE) is a frequent and common complication of cirrhosis, affecting nearly 80% of cirrhotic patients. Physical examination in MHE is often normal; patients may present subtle abnormalieties, interfering with executive function, including their working memory and orientation, impairment of social interaction, emotional behavior, sleep disorders, physical and mental symptoms, and diminished Quality of Life (QoL) [1]. This underrecognized and underdiagnosized syndrome often presents minimal changes in personality and in memory, intellectual function, concentration, and coordination. Conclusions: Resveratrol showed efficacy in the treatment of depression, anxiety, and ammonia serum levels, and improved the quality of life Of MHE patients
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