Abstract
Background: Resveratrol, a natural polyphenolic phytoalexin, is broadly presented in dietary sources. Previous research has suggested its potential neuroprotective effects on ischemic stroke animal models. However, these results have been disputable. Here, we conducted a meta-analysis to comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models. Objective: To comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models. Methods: A literature search of the databases Pubmed, Embase, and Web of science identified 564 studies that were subjected to pre-defined inclusion criteria. 54 studies were included and analyzed using a random-effects model to calculate the standardized mean difference (SMD) with corresponding confidence interval (CI). Results: As compared with controls, resveratrol significantly decreased infarct volume (SMD −4.34; 95% CI −4.98 to −3.69; p < 0.001) and the neurobehavioral score (SMD −2.26; 95% CI −2.86 to −1.67; p < 0.001) in rodents with ischemic stroke. Quality assessment was performed using a 10-item checklist. Studies quality scores ranged from 3 to 8, with a mean value of 5.94. In the stratified analysis, a significant decrease of infarct volume and the neurobehavioral score was achieved in resveratrol sub-groups with a dosage of 20–50 mg/kg. In the meta-regression analysis, the impact of the delivery route on an outcome is the possible source of high heterogeneity. Conclusion: Generally, resveratrol treatment presented neuroprotective effects in ischemic stroke models. Furthermore, this study can direct future preclinical and clinical trials, with important implications for human health.
Highlights
Ischemic stroke is one of the major causes of morbidity and long-term disability in the worldwide population
Based on the data of this meta-analysis, resveratrol treatment presents neuroprotection compared with control groups, by assessing the treatment outcomes including infarct volume, and neurobehavioral score
The results of this meta-analysis may provide certain references and a baseline for further preclinical and clinical studies with important implications for human health
Summary
Ischemic stroke is one of the major causes of morbidity and long-term disability in the worldwide population. Resveratrol (3,5,4′-trihydroxystilbene) (PubChem CID: 445154) is a natural estrogen-like phytosterol that mainly is found in grapes, blueberries, peanuts, red wine, Semen Cassiae, and other dietary constituents (Walle, 2011) This compound exists in two isoforms cis- and trans-resveratrol, the isomer trans being more active than the cis-form (Amri et al, 2012). There is no meta-analysis available investigating the potential effects of resveratrol therapy in preclinical models of ischemic stroke. Addressing all these problems, we systematically assessed the bias of included studies and summarized the optimal pattern of resveratrol therapy. Previous research has suggested its potential neuroprotective effects on ischemic stroke animal models We conducted a meta-analysis to comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models
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