Abstract
Resveratrol has been described to possesses several biological activities such as antioxidant, antimicrobial, anti-inflammatory and anticarcinogenic. However, its in vivo efficacy is still limited owing to its low aqueous solubility. The main goal of this study is to increase resveratrol aqueous solubility using for this purpose randomly methylated-β-cyclodextrin. Inclusion complex (IC) characterization and dissolution studies were performed as well as the evaluation of the IC antioxidant, cytotoxicity and anti-Campylobacter activities. Resveratrol complexation caused an effective 400 fold improvement in its aqueous dissolution. Both resveratrol and IC showed good antibacterial activity against Campylobacter spp. with minimum inhibitory concentration values ranging from 50 to 100 μg/mL for pure resveratrol and from 64 to 512 μg/mL for the IC, while also exhibiting a very good antioxidant activity and no haemolytic activity. Resveratrol complexation with methylated-β-cyclodextrin increased its solubility while maintaining resveratrol's biological properties.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
