Resveratrol And Its Derivative Improves Oxidative Stress and Protects Against Alloxan- Induced Diabetics

Abstract

Resveratrol is a non flavonoid polyphenol and it has three phenolic hydroxyl groups and shown to have its biological effects . Reactive oxygen species play a crucial role in the pathogens of diabetes and its complication, this study aims to examine the effects of resveratrol and its derivative on alloxan induced diabetics. Statistical analysis showed a significant decrease in SOD , GSH, Gpx, Zn and Cu concentration and significant increase in MDA level on diabetic rabbits p<0.05 , however diet supplemented with resveratrol derivative induced a significant increase of copper and zinc 1.43±0.01 ppm, 0.79 ± 0.02 ppm respectively after sixth weeks of treatment as compared with control 1.13 ± 0.03ppm, 0.66 ± 0.01ppm respectively. . The administration of resveratrol derivative to rabbits resulted in the significant decrease of MDA levels after three weeks to 2.42±0.08 nanomole /ml and 1.56±0.02 nanomole/ml after sixth weeks as compared with control group 2.43 ± 0.2778 nanomole /ml. The diabetic rabbits presented a significant increase in the SOD activity after treatment by resveratrol derivative after sixth weeks 4.24 ± 0.02 U/ml as compared with control during the experimental period, glbcimide treated group show a significant decrease in SOD activity after sixth weeks . In addition, there was a significant increase in Gpx activity119.77±0.01 U/L in resveratrol derivative treated group after sixth weeks. In infected animals was a decrease level of GSH when drug and purified resveratrol treated rabbits, while resveratrol derivative has normal value after three weeks of treatment 11.17 ± 0.03 μ mole/L and 19.82 ±0.01 μ mole/L after sixth weeks. The results suggest thatresveratrol derivative may be helpful in preventing diabetic complications in rabbits.