Abstract
Citing recent retrospective data showing that resuscitation with fresh whole blood (FWB) rather than crystalloid and blood components resulted in decreased mortality among injured soldiers, the authors of this article hypothesized that the transfusion of FWB results in less systemic inflammation and organ injury compared to crystalloid resuscitation after hemorrhagic shock. They employed a mouse model of hemorrhagic shock, cannulating the femoral arteries of mice and then assigning them to one of four arms: a sham group (no hemorrhage or resuscitation), hemorrhage without resuscitation, resuscitation with lactated ringer's solution (LR), and resuscitation with FWB.
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