Abstract
OBJECTIVE: Both luteinizing hormone (LH) and follicle stimulating hormone (FSH) are needed for successful ovarian stimulation. The role of LH supplementation in normogonadotropic women is questionable. It was shown in animal and human experiments that androgens (testosterone, DHEA) administered prestimulation or in the early follicular phase increase theca layer thickness, antral follicle count, appear to increase granulosa cell FSH sensitivity and result in improved pregnancy rates. The aim of our study was to assess whether recombinant LH given in the early follicular phase increases FSH sensitivity through increasing theca cell androgen synthesis and therefore improves stimulation parameters and/ or pregnancy rates during IVF.
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