Abstract
Objectives: To describe the clinical and subclinical characteristics of patients with Paget's disease of the breast at The National Cancer Hospital and to evaluate the treatment outcomes of Paget's disease of the breast. Materials and methods: 46 patients were diagnosed and treated for Paget's disease of the breast in the Breast Surgery Department of The National Cancer Hospital from 2016 to 2020. Results: The average age was 60.6 ± 10.8. The common symptoms were nipple pain (76.1%) and nipple ulceration (65.2%). Paget's disease with invasive ductal carcinoma accounted for 37.0%, and Paget's disease with intraductal carcinoma accounted for 28.2%. The proportions of breast cancer stages 0, 1, 2, and 3 were 63.0%, 23.9%, 8.7%, and 4.4%, respectively. The proportions of total mastectomy and breast-conserving surgery were 97.8% and 2.2%, respectively. The 5-year overall survival and disease-free survival rates were 91.3% and 84.8%, respectively. Conclusions: A high proportion of Paget's disease of the breast cases are associated with underlying ductal carcinoma. Surgical treatment of Paget's disease has achieved positive outcomes in terms of overall survival and disease-free survival. Received 27 June 2023Revised 25 September 2023Accepted 28 November 2023
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