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Abstract
Background. The increased incidence of inflammatory bowel disease (IBD) in the world and the lack of consensus on the causes and development mechanisms of IBD are the key elements that determine the relevance of the study. According to some authors, in the pathogenesis of the development and occurrence of ulcerative colitis, one of the leading causes is a change in the composition of the colon microflora and the impact of the products of their metabolism on the enteric system and intestinal motility. The aim was to study the qualitative and quantitative changes in the colon microbiota in rats when modeling ulcerative lesions by the original method. Materials and methods. The experimental study was carried out using male Wistar rats ( n = 24). Ulcerative colitis was modeled in an original way. The quantitative and qualitative composition of the parietal microflora of the distal colon was determined. Results . When modeling ulcerative lesions of the colon using the original method, changes in the qualitative and quantitative composition of the parietal microflora of the colon were revealed. On the 3 rd day there was a decrease in Lactobacillus ssp. and Escherichia coli , as well as the growth of fungal microflora and the appearance of representatives of opportunistic microflora. The changes were progressive in nature, and by the 7 th day of the study revealed a marked reduction of the total parietal concentration of the normal flora bacteria and an increased percentage and absolute number of representatives of conditionally pathogenic microflora. By the 10 th day of the experiment, with a small increase in the total number of parietal bacteria, the predominant microorganisms were Bacteroides ssp. (26.8%) and Peptococcus ssp. (27.6%).
Highlights
The increased incidence of inflammatory bowel disease (IBD) in the world and the lack of consensus on the causes and development mechanisms of IBD are the key elements that determine the relevance of the study
In the pathogenesis of the development and occurrence of ulcerative colitis, one of the leading causes is a change in the composition of the colon microflora and the impact of the products of their metabolism on the enteric system and intestinal motility
Ulcerative colitis was modeled in an original way
Summary
Язвенный колит – хроническое рецидивирующее системное воспалительное заболевание с преимущественным поражением слизистой оболочки толстой кишки. В патогенезе развития и возникновения заболевания одну из ведущих причин играет изменение в составе микрофлоры толстой кишки, а также продукты их метаболизма, воздействующие на энтериновую систему и моторику кишечника. Изучить показатели микробиоты толстой кишки у самцов крыс линии Вистар при моделировании язвенного поражения. Определен количественный и качественный состав пристеночной микрофлоры дистального отдела толстой кишки. Выявлены изменения качественного и количественного состава пристеночной микрофлоры толстой кишки: на 3-и сут отмечали снижение концентрации Lactobacillus ssp. И уже к 7-м сут выявляли выраженное снижение общей пристеночной концентрации бактерий нормофлоры и повышение процентного и абсолютного числа представителей условно-патогенной микрофлоры. Результаты оценки микробиоты в условиях экспериментального язвенного поражения толстой кишки. Ким А.Д., Лепехова С.А., Чашкова Е.Ю. и др
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