Abstract
Postoperative recurrence (POR) after an ileocolonic resection with ileocolonic anastomosis is frequently encountered in patients with Crohn's disease. The 8 th Scientific Workshop of ECCO reviewed the available evidence on pathophysiology and risk factors for POR. In this manuscript, we will discuss published data on the role of the microbiome, the mesentery, the immune system, and the genetic background. In addition to the investigation of causative mechanisms of POR, identification of risk factors is essential to tailor preventive strategies. Potential clinical, surgical and histological risk factors are presented along with their limitations. Emphasis is placed on unanswered research questions, guiding prevention of POR based on individual patient profiles.
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