Results of simultaneous intervention in patients with concomitant coronary artery disease and aortic stenosis

Abstract

<p><strong>Aim.</strong> The study was aimed at comparing the immediate and long-term results of aortic valve replacement in combination with various techniques of intervention for myocardial revascularization, namely: coronary artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA).<br /><strong>Methods.</strong> This randomized prospective controlled study involved 120 cardiac patients over 18 years old with combined aortic valve stenosis and arterial sclerotic disease of coronary arteries. The inclusion criteria were a combination of aortic valve stenosis and a hemodynamically significant lesion of the coronary bed. A comparative analysis of the results obtained in the nearest postoperative period and during 1-year follow-up is presented. <br /><strong>Results.</strong> Hybrid intervention (aortic valve replacement + percutaneous transluminal coronary angioplasty) produces the results which are comparable with those of the control (aortic valve replacement + CABG), with a significantly greater decrease in the peak gradient on the aortic valve. During long-term follow-up, the group of patients who underwent hybrid intervention demonstrated a much higher myocardial infarction rate (12.5 versus 2.5 %, however, the severity of infarctions was significantly lower.<br /><strong>Conclusion.</strong> PTCA, as compared to CABG, with concomitant coronary artery disease significantly improves the indicators of aortic valve insufficiency and the survival after repeated myocardial infarction, with the matching frequency of acute cerebral circulation abnormalities and the lethality rate in the long-term period.</p><p>Received 29 August 2016. Accepted 5 October 2016.</p><p><strong>Funding:</strong> The study had no sponsorship. <br /><strong>Conflict of interest:</strong> The authors declare no conflict of interest.</p>