RESULTS OF RADIOSURGICAL TREATMENT OF PATIENTS WITH METASTATIC BRAIN LESION

Abstract

Objective: To study the overall survival and intracranial relapse in patients with brain metastases (BM) after radiosurgical treatment (SRS) on the machine Gamma Knife. Material and Methods: The analysis of treatment results in 416 patients with BM (178 men and 238 women) was conducted. Patients with radiosensitive tumors: breast cancer (n = 113; 27,1%) and non-small cell lung cancer (n = 119; 28,6%) prevailed. 222 patients (53.4%) had multiple (4 or more niduses) BM. The median of cumulative volume and the number of BM was 5,3 cm3 (0,09-56,6) and 5 (1-39), respectively. The average marginal dose of ionizing radiation was 21 Gy (range 15-24 Gy). The average time of clinical follow-up was 11,7 months (0.2-64.4 months). Results: The overall survival of patients for 12 and 24 months was 34,5% and 20,9%, respectively. The median overall survival after SRS was 7,5 months (95% confidence interval (CI) - 5,0-9,0). The local control of BM was achieved in 88,0% of the patients. The development of new BM was reported in 37,1% of the patients. The median time without progression was 10,6 months (95% CI 8,5-18,7). KPS > 70, BM radiosensitive tumors, limited (3 or less) BM and absence of extracranial metastases are the best predictors of better survival. Conclusions: Implementation of SRS in patients with BM provides median overall survival equal to 10.0 months. The KPS >70, BM <3 lesion, radiosensitive morphology of primary tumor and absence of extracranial metastases are predictors of better survival.