Results of long-term permeability of small-diameter vascular prostheses modified by pro-angiogenic factors and athrombogenic drug coating (model of large laboratory animals)

Abstract

Developed for bypass surgery, tissue-engineered vascular grafts should remain passable after implantation and have high rate of endothelialization to ensure long-term patency, atrombogenicity and biocompatibility. This study was aimed at assessing the long-term patency of polyhydroxybutyrate/valerate (PHBV)/polycaprolactone (PCL) vascular grafts modified by pro-angiogenic factors and athrombogenic drug coating in a large laboratory animal model.