Abstract
A total of 286 knitted vascular prostheses made of polyethylene terephthalate and surface-treated with polyurethane, polylactide, or both were implanted over the past 6 years. Of this total number, 224 prostheses were implanted in rats, nine in dogs, and 53 in pigs. We developed 39 types of knitted prostheses. The best results were obtained with prosthesis no. 36, which was surface-treated with polyurethane and polylactide. Prostheses 10 mm in length with a diameter of 2 mm implanted into rat aortas showed 100% patency during the observation periods of 2 months (ten implants) and 1 year (40 implants). Although various antithrombotic treatment schemes were tested, implantations of 5-cm- to 10-cm-long no. 36 prostheses in dogs were unsuccessful. The results of implantation of 3-mm caliber no. 36 prostheses to pigs were comparable with those obtained with Gore-Tex prostheses. Intensive antithrombotic treatment with heparin and Rheomacrodex intraoperatively followed by Fraxiparine (0.3 ml/12 h), was necessary to ensure early patency of the implants. Lower dosage of antithrombotic drugs resulted in transient incomplete occlusion of the implant. Full patency resumed after 1 month.
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