Results of art without PGD among patients with reciplocal translocation and robertosonian translocation

Abstract

Chromosome abnormality is one of the major causes of infertility. In Japan, only PGD regarding patients with severe genetic disorders and balanced translocations experienced with recurrent abortion are permitted. The purpose of this study is to compare results of ART without PGD between reciprocal translocation and Robertsonian translocation. This is a retrospective analysis of clinical outcome between January of 1999 and July of 2014. Thirty-nine reciprocal translocations (29 men and 10 women) and 24 Robertsonian translocations (21men and 3 women) were enrolled in the study. Among 29 couples with men’s reciprocal translocation, 61 fresh embryo transfers and 33 frozen-thawed embryo transfers were performed. Among 10 couples with women’s reciprocal translocation, 14 fresh embryo transfers and 8 frozen-thawed embryo transfers were performed. On the other hand, among 21 couples with men’s Robertsonian translocation, 38 fresh embryo transfers and 29 frozen-thawed embryo transfers were performed. Among 10 couples with women’s Robertsonian translocation, 4 fresh embryo transfers and one frozen-thawed embryo transfer were performed. The clinical pregnancy rate per embryo transfer among couples with men’s reciprocal translocation was comparable with that among couples with women’s reciprocal translocation (26.6% vs 27.3%). The delivery rate per embryo transfer among couples with men’s reciprocal translocation was also comparable with that among couples with women’s reciprocal translocation (14.9% vs 13.6%). On the other hand, the clinical pregnancy rate per embryo transfer among couples with men’s Robertsonian translocation was comparable with that among couples with women’s Robertsonian translocation (40.3% vs 40.0%). The delivery rate per embryo transfer among couples with men’s Robertsonian translocation was also comparable with that among couples with women’s Robertsonian translocation (31.3% vs 40.0%). Next, the clinical pregnancy rate per embryo transfer among couples with reciprocal translocation was comparable with that among couples with Robertsonian translocation (26.7% vs 40.3%). The abortion rate per embryo transfer among couples with reciprocal translocation was also comparable with that among couples with Robertsonian translocation (21.4% vs 12.5%). However, the delivery rate per embryo transfer among couples with reciprocal translocation was significantly lower than that among couples with Robertsonian translocation (14.7% vs 31.9%: P<0.01). In the case of performing ART without PGD, the delivery rate per embryo transfer among couples with reciprocal translocation was significantly lower than that among couples with Robertsonian translocation.