Abstract
The results of the use in the experiment of composite hydrogel coatings of prolonged action based on polyvinyl alcohol are investigated.Objective. The aim of the study is a comparative clinical assessment of the effectiveness of the developed composite hydrogel coatings of prolonged action in an experiment in laboratory rats.Materials and research methods. After modeling alloxan diabetes mellitus and neuroischemic form of diabetic foot in laboratory white Wistar rats, the developed wound dressings were applied. A clinical analysis of their effectiveness was carried out and the optimal composition was determined. The animals were divided into three groups, 10 animals in each group, as follows: the first — control with self-healing of the wound, the second — with samples No. 1 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin), the third — with samples No. 2 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin + methyluracil). The first dressing change was carried out on the third day with the taking of histological material, then - every other day. When changing the dressing, such parameters as the nature and amount of wound discharge, the size of the ulcer, the presence of granulations and epithelialization were assessed. Dynamic assessment was performed on the 3rd, 7th, 14th and 21st days. The measurement of the area of the ulcer was carried out by transferring the contour of the ulcer to graph paper with manual counting.Research results. The healing rate of ulcers in the experimental groups was higher than in the control group. When comparing second and third groups, a significant increase in speed was noted by the seventh day in third group (p < 0.05), which reduced the overall healing time of ulcers by 7 days.Conclusion. The study showed that the healing time of ulcers in laboratory animals with the use of the developed wound dressings is significantly reduced in comparison with the control group. The proposed method of local treatment can be considered effective in the treatment of vascular etiology trophic ulcers against the background of diabetes mellitus.
Highlights
When comparing second and third groups, a significant increase in speed was noted by the seventh day in third group (p < 0.05), which reduced the overall healing time of ulcers by 7 days
The study showed that the healing time of ulcers in laboratory animals with the use of the developed wound dressings is significantly reduced in comparison with the control group
The proposed method of local treatment can be considered effective in the treatment of vascular etiology trophic ulcers against the background of diabetes mellitus
Summary
The aim of the study is a comparative clinical assessment of the effectiveness of the developed composite hydrogel coatings of prolonged action in an experiment in laboratory rats. A clinical analysis of their effectiveness was carried out and the optimal composition was determined. The first dressing change was carried out on the third day with the taking of histological material, - every other day. When changing the dressing, such parameters as the nature and amount of wound discharge, the size of the ulcer, the presence of granulations and epithelialization were assessed. When comparing second and third groups, a significant increase in speed was noted by the seventh day in third group (p < 0.05), which reduced the overall healing time of ulcers by 7 days
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