Results of a Strength and Balance Training Pilot Study for Colorectal Cancer Survivors with Peripheral Neuropathy Caused by Oxaliplatin

Abstract

Background and Purpose: Strength and balance exercises may help alleviate neuropathic symptoms and improve strength and balance. The purpose of this single group, descriptive study was to pilot a 12-week, bi-weekly, group exercise program designed to improve lower extremity strength and balance with persons with oxaliplatin induced peripheral neuropathy and evaluate its (1) feasibility; (2) tolerability; and (3) effects on strength, balance, and neuropathic symptoms. Methods: Colorectal cancer survivors with neuropathy living within driving distance to the University were recruited. Lower extremity muscle strength was measured using a dynamometer. Balance was measured using unipedal stance time, Timed Up and Go, Modified Clinical Test for Sensory Interaction in Balance, and Dynamic Gait Index. Neuropathy symptoms were measured using the Chemotherapy Induced Peripheral Neuropathy Assessment Tool and Total Neuropathy Score. Data were analyzed using descriptive statistics. Results: 311 colon cancer survivors were contacted regarding the study and advertisements were placed in local newspapers, yet only 12 patients expressed interest, of which 8 were unavailable at the time of the intervention, 4 enrolled, and 3 people completed the study. Patients reported that the exercise intervention was tolerable and difficulty level was appropriate. Neuropathy, balance, and strength demonstrated improvement. Conclusions: The intervention showed promise for improving balance, strength and reducing neuropathic symptoms among patients who completed the study. Recruiting cancer survivors for this study was challenging. Future studies should take into account barriers such as transportation, scheduling, and time commitment.