Abstract
This study defined the impact of oral mucositis (OM) on outcomes in patients with multiple myeloma (MM) after autologous transplant who were receiving low-level laser therapy (LLLT). Methods: A total of 79 patients with MM were evaluated retrospectively. We examined the relationship between the worst OM grade and clinical outcomes. Results: Of 79 patients, 55 experienced OM grade 0-1, 16 OM grade 2, 7 grade 3, and 1 grade 4. Patients with OM grade 0-2 had statistically fewer days of oral pain compared with those with grade 3-4 (0.88 and 6.25 days, respectively). The worst OM grade was also significantly associated with days of narcotic therapy and length of LLLT. Severe OM was associated with worse clinical outcomes. Conclusion: In this transplantation setting, severe OM was not as common as previously reported in literature, probably due to LLLT. Controlled randomized trials should be performed to confirm the real benefit of LLLT.
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