Results of a 7-year prospective follow-up in the Interepid study: factors influencing all-cause and cardiovascular mortality in rural residents of Russia and the Kyrgyz Republic

Abstract

Aim. To assess the 7-year survival rate and the association of risk factors (RFs) with all-cause and cardiovascular mortality among rural residents in Russia and the Kyrgyz Republic, as well as to analyze ethnic characteristics (according to the Interepid study).Material and methods. This study was carried out within the Interepid international project, which included a cross-sectional epidemiological study of the prevalence of major noncommunicable diseases and their risk factors in 2011- 2012, and a prospective stage among rural residents of two countries (Russia, the Kyrgyz Republic). In 2019, the vital status of respondents was reassessed (7 years after the initial examination), and endpoints were collected, including all-cause and cardiovascular deaths.Results. A significant similarity of rural residents of the analyzed regions in relation to the factors associated with mortality was revealed. Smoking in men, obesity in women, and hypertension in both sexes were associated with an increased death risk. Country differences were found only in relation to low physical activity and dietary habits. Ethnic developments in the population of the Kyrgyz Republic also concerned only the contribution of food habits.Conclusion. The results obtained are important for planning, implementing and evaluating the effectiveness of public health promotion programs. It is also necessary to develop differentiated treatment and prevention measures in the Russian population and among the indigenous inhabitants of the Kyrgyz Republic, including taking into account the prevalence of CVD risk factors and their impact on life prognosis.