Abstract
Background and Aims: LIB003 (LIB) is a novel highly potent small, recombinant fusion protein with a PCSK9-binding domain (adnectin) and human serum albumin. In Phase 2 dose ranging trial mean placebo-adjusted LDL-C reductions were 77.3% with 300 mg (1.2 mL) Q4W dosing. We assessed the 52-week (Wk) safety and efficacy of LIB 300 mg Q4W in an open label extension (OLE) trial.
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