Results in Treatment of 374 Mann-Williamson Dogs

Abstract

Summary The average survival time of our control (untreated) Mann-Williamson series was 63 days. All died of ulcer. The longest survival was 135 days. Eight per cent of the ulcers showed epithelization. With these data as a base line, our results are as follows: (1)Best results were obtained by daily injections of commercial human pregnancy urine extract (Antuitrin-S). Inactivating this by heat destroyed much of its potency. Marked benefit was obtained from extracts of normal male and normal female urine (parenteral administration) which did not contain the anterior pituitary-like hormone. Extracts made from urine of ulcer patients, administered parenterally, had very much less, if any, activity. (2)Oral administration of a human pregnancy urine extract, in small doses, failed to prolong the survival time, but it stimulated epithelization in a significant number of the ulcers. (3)The follicle-stimulating hormone from pregnant mare's serum (Gonadogen) was definitely beneficial (parenteral therapy). (4)Parenterally, the posterior pituitary extract (surgical pituitrin) was of no benefit. A combination of the posterior pituitary extract (pituitrin) and the anterior pituitary-like or luteinizing hormone (Antuitrin-S) failed to prolong the survival time but a significant number of the animals died without ulcer. (5)Estrone (Theelin) administered by injection, failed to produce any effect. Progesterone (Proluton), also by injection, did not prolong the survival time of the animals but it stimulated epithelization. (6)An extract obtained from urine of patients with inoperable carcinoma of the stomach and an extract prepared from beef heart muscle tissue (each used parenterally) produced some benefit. The number of animals in these two series is too small for definite conclusions. (7)Parenteral administration of a foreign protein from def atted milk (aolan) prolonged the survival time slightly. Not one of the ulcers examined microscopically showed epithelization. (8)Oral enterogastrone was of some benefit. Very little, if any, effect was obtained with the parenterally administered enterogastrone we used. (9)Vagotomy had no beneficial effect. (10)All of our Mann-Williamson animals with total gastrectomy died without ulcer. However, because of the nutritional disturbances that followed, all the animals died within 40 post-operative days.