Abstract
BackgroundTo evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery.MethodsA prospective, observational study of all patients submitted to cataract surgery over the period January 1996 to December 2009. All cases of postoperative endophthalmitis over that period were reviewed. The patients were classified in two groups: Group 1 (11,696 patients) operated on between January 1996 and December 2002, Group 2 (13,305 patients) between January 2003 and December 2009 (in whom a 1 mg/0.1 bolus of intracameral cefazolin was instilled).ResultsDuring the study period, 76 cases of endophthalmitis were observed in Group 1, and seven in Group 2. The rate of postoperative endophthalmitis reduced from 0.63% to 0.05% with a cefazolin injection. The relative risk (RR) for endophthalmitis in Group 1 against group 2 was 11.45 [95% CI 5.72-22.84, p < 0.001].ConclusionsAn intracameral bolus injection of cefazolin (1 mg in 0.1 ml solution) at the conclusion of the cataract surgery significantly reduced the rate of postoperative endophthalmitis.
Highlights
To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery
In the table we presented only the results obtained with the bacteria cultured in endophthalmitis observed in our area, and compared with the prophylactic antibiotics most frequently used for endophthalmitis in Spain
We found Corynebacterium, Klebsiella pneumonia, Pseudomona aeroginosa, and Proteus mirabilis in group 2
Summary
To evaluate results after seven years using prophylactic intracameral cefazolin for the prevention of endophthalmitis in cataract surgery. Endophthalmitis remains a serious complication after cataract surgery, prophylactic measures introduced in recent years have reduced the number of patients with this complication. Our two groups are included in the Barcelona Endophthalmitis Group (GEB), formed by 38 public and private Hospitals in Catalonia (Spain), who have been studying the epidemiological factors of postoperative endophtalmitis and assessing the prophylaxis and treatment of endophtalmitis in our country since 2000. This study will present the results obtained after seven years of using intracameral cefazolin after cataract surgery at doses of 1 mg in 0.1 ml
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