Abstract
This chapter describes some methodological problems in higher nervous activity (HNA) studies, HNA alterations in schizophrenia, special features of the HNA in various forms and stages of schizophreni, and changes of the HNA in schizophrenia under treatment. The basis of stupor, negativism, delusions, and some hebephrenic features in the behavior of schizophrenic patients is proposed to be an external, trans-marginal inhibition, taking place in different cortical mechanisms. Thus, investigations on the HNA in schizophrenia have contributed to a better understanding of the pathogenetic and pathophysiological mechanisms involved in this severe mental disease and in its various forms and stages. The practical results of value are demonstrated to prognostic prediction and to evaluation of recovery. Further lines of research on the HNA in schizophrenia are suggested.
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