Abstract
A comparison of the anti-lactose IgM response among individual animals of five inbred strains of mice has been made with a view to possible germ-line restriction in IgM diversity. The V H regions of the antibodies were isolated and the individual preparations examined by isoelectrical focusing (IEF) in 7 M urea. The main findings were the complexity of the IEF patterns as well as their similarity among individuals of the same strain and their near-identity to the patterns for the V H regions derived from normal IgM. These observations parallel results found earlier with V H preparations of equine anti-lactose IgM. This homology of behavior between the two systems suggests a cautious generalization about IgM responses to the effect that limited longevity of the B cell clones and germ-line restriction of V H in IgM expression remain tenable notions.
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