Abstract
The development of oligonucleotide probes has improved investigations into multiple gene family-like HLA genes by eliminating the cross hybridization bands observed with cDNA probes. We therefore examined the serologically ill-defined antigen DR5 using Bam HI restriction endonuclease with an oligonucleotide probe specific for DR-β (37mer, probe site: amino acid residues 81–93) (1). The Ninth International Histocompatibility Workshop split DR5 into DRwll and DRw12 and recently, a monoclonal antibody HU-39, which recognizes DN1, has been reported as useful in typing DRw12. Therefore, we also investigated RFLP in families and donors that possess DN1 in order to understand the relationship between DN1 and DR5.
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