Abstract
RESULTS from three distinct experimental systems indicate that, except for lymphocytes reacting to alloantigens, interaction between sensitised thymus-derived lymphocytes (T cells) and other somatic cells occurs only in syngeneic or semiallogeneic systems. First, histoincompatible T cells do not function as helpers for antibody-forming cell precursors (B cells)1,2. Second, maximal proliferation of lymphocytes (presumably T cells) resulting from exposure in vitro of sensitised guinea pig lymphocytes to antigen-pulse macrophages is observed only when the two cell types share major histocompatibility antigens3. Third, cell-mediated lysis of fibroblasts or macrophages infected with lymphocytic choriomeningitis (LCM) virus, a function of specifically sensitised T cells, occurs only when lymphocyte and target cells share at least one set of H-2 antigenic specificities4,5. The phenomenon is unaffected by differences either in minor histocompatibility antigens, or at the M locus.
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