Abstract
Mouse kidney cells (Balb/c cells), in which mouse adenovirus strain FL (Ad FL) replicates, become restricted in their capacity to support Ad FL growth after transformation by simian adenovirus 7 (SA7). In transformed cells (Balb/c SA7 cells), the duration of the Ad FL cycle is significantly longer than in normal cells; some virus DNA replication and virus protein synthesis occur but the yield of infectious Ad FL particles is greatly reduced. Only a few cells produce virus as estimated by the number of infectious centers. However, no significant differences are noted in the adsorption and in the penetration of Ad FL in both cell types. Thus, the restrictive event in virus multiplication in Balb/c SA7 cells occurs probably after viral uncoating and before viral DNA synthesis.
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