Abstract
Aging impairs epidermal differentiation and barrier function, making aged skin susceptible to dryness, dermatitis and infection. Here, we show that pharmacologically enhancing endoplasmic reticulum Ca2+ stores with CDN 1163, a small molecular SERCA2b allosteric activator, corrects age-related defects in Ca2+ storage in aged keratinocytes, partially corrects the abnormal Ca2+ gradient seen in aged epidermis, and enhances filaggrin expression in aged skin samples.
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