Abstract
Objectives: The melanocortin 4 receptor (MC4R) belonging to the large superfamily of G-protein coupled receptors plays a crucial role in hypothalamic weight regulation. In approximately 3–5% of investigated obese patients inactivating MC4R mutations are the underlying molecular cause for early onset obesity. Functional characterisation revealed for specific partial loss of function MC4R mutations that restoration of receptor function is possible by usage of highly potent MC4R analogs. The analogue NDP-α-MSH is capable to restore wild type signalling in some cases of partial loss of function. However, for total loss of function receptors this procedure is insufficient.
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