Abstract
After subcapsular transplantation of tibial bone marrow, locally irradiated in a dose of 2000 R, into the kidney of mice of the same line 0–4 months after irradiation, resporption always took place. Meanwhile, bone marrow from the unirradiated limb of the same donors always possessed osteogenic potential. The stroma of the irradiated limb was defective and did not regenerate by repopulation of the stromal cells from unirradiated areas. Experiments in which mice were irradiated repeatedly and the same limb was shielded gave similar conclusions. The results of heterotopic transplantation show that stromal cells, unlike hematopoietic cells, cannot repopulate.
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