Abstract
The effects of elevated glucose and eicosapentaenoic acid (EPA, C20:5 ω3) on myo-inositol uptake in human skin fibroblasts (HSF) were evaluated. Myo-inositol incorporation into HSF was dependent on an active transport system via Na +-K + ATPase activity based on the results with Na + deprivation and ouabain (5 mM). Although glucose (27.5, 55 mM) inhibited 2-[ 3H] myo-inositol uptake, the addition of EPA (3×10 −4M) prevented glucose-mediated inhibition. Since EPA decreased glucose-mediated inhibition of myo-inositol uptake, this agent might ameliorate some of the devastating functions associated with diabetes.
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