Abstract
Whole body irradiation with 780 rads suppressed humoral and cell-bound immune responses in rats. Rats were immunized with bovine serum albumin 24 hr after 780 rads and given normal syngeneic lymphoid cells. Lymph node, thoracic duct or spleen cells were more effective than thymus or bone marrow cells in increasing delayed hypersensitivity responses. Spleen cells (10 7) increased both delayed hypersensitivity and antibody responses. However, with lymph node and thoracic duct cells 10 6 cells increased delayed hypersensitivity but 10 7 or 2.5 × 10 7 cells were needed to improve antibody responses. Cells from donors tolerant to bovine serum albumin affected neither delayed hypersensitivity nor antibody formation.
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