Abstract
ABSTRACT The effect of Aegle marmelos fruit extract on some key carbohydrate metabolic enzymes was studied in streptozotocin-induced diabetic Wistar rats. Diabetic rats exhibited a decrease in the activity of hexokinase and an increase in the activities of glucose 6-phosphatase and fructose 1,6-bisphosphatase in serum, liver, and kidney. All the alterations in the activities of these enzymes were brought back to near normalcy by oral administration of Aegle marmelos fruit extract for a period of one month, twice a day. The effect of the extract at a dose of 250 mg/kg was more effective than glibenclamide (300 μg/kg).
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