Resting-state EEG Dynamics Reveals Differences in Network Organization and its Fluctuation between Frequency Bands

Abstract

Functional connectivity in EEG resting-state is not stable but fluctuates considerably. The aim of this study was to investigate how efficient information flows through a network, i.e. how resting-state EEG networks are organized and whether this organization it also subject to fluctuations. Differences of the network organization (small-worldness), degree of clustered connectivity, and path length as an indicator of how information is integrated into the network across time was compared between theta, alpha and beta bands. We show robust differences in network organization (small-worldness) between frequency bands. Fluctuations in network organization were larger in the theta, compared to the alpha and beta frequency. Variation in network organization and not the frequency of fluctuations differs between frequency bands. Furthermore, the degree of clustered connectivity and its modulation across time is the same across frequency bands, but the path length revealed the same modulatory pattern as the small-world metric. It is therefore the interplay of local processing efficiency and global information processing efficiency in the brain that fluctuates in a frequency-specific way. Properties of how information can be integrated is subject to fluctuations in a frequency-specific way in the resting-state. The possible relevance of these resting-state EEG properties is discussed including its clinical relevance.