Year-end Sale % OFF 
Abstract
Recently, studies based on time-varying functional connectivity have unveiled brain states diversity in some neuropsychiatric disorders, such as schizophrenia and major depressive disorder. However, time-varying functional connectivity analysis of resting-state functional Magnetic Resonance Imaging (fMRI) have been rarely performed on the Autism Spectrum Disorder (ASD). Hence, we performed time-varying connectivity analysis on resting-state fMRI data to investigate brain states mutation in ASD children. ASD showed an imbalance of connectivity state and aberrant ratio of connectivity with different strengths in the whole brain network, and decreased connectivity associated precuneus/posterior cingulate gyrus with medial prefrontal gyrus in default mode network. As compared to typical development children, weak relevance condition (the strength of a large number of connectivities in the state was less than means minus standard deviation of all connection strength) was maintained for a longer time between brain areas of ASD children, and ratios of weak connectivity in brain states varied dramatically in the ASD. In the ASD, the abnormal brain state might be related to repetitive behaviors and stereotypical interests, and macroscopically reflect disruption of gamma-aminobutyric acid at the cellular level. The detection of brain states based on time-varying functional connectivity analysis of resting-state fMRI might be conducive for diagnosis and early intervention of ASD before obvious clinical symptoms.
Highlights
Autism Spectrum Disorder (ASD) is a lifelong developmental disorder
Functional connectivity of ASD children showed weak connectivity for a longer time as compared to typical development (TD) children according to the Tvalues
The connectivity state in the brain is flexible, which might correspond to diversity of human cognitive functions
Summary
Autism Spectrum Disorder (ASD) is a lifelong developmental disorder. Children with ASD cannot perform normal social communication, and are characterized by repetitive behaviors and stereotypical interests. Previous studies indicated that impairments in the ASD might reflect deficits in brain network and connectivity (Minshew and Williams, 2007; Vissers et al, 2012; Abbott et al, 2015). Deficits in connectivity have been found to be related to clinical symptoms and behavioral performance in the ASD. Underconnectivity and overconnectivity have been detected in functional connectivity analysis of ASD. In the studies about ASD based on working memory, executive functioning, and response inhibition tasks, the underconnectivity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
