Abstract
Every day, 130+ people in the U.S. die of opioid use disorder (OUD) overdoses - with OUD prevalence quadrupling from 1999 to 2014. About 100,000 women per year may receive buprenorphine replacement treatment (BT) to prevent withdrawal. Despite concerns from animal models of opioid-induced deficits in maternal behavior and a human Maternal Behavior Neurocircuit model to investigate, little is known about brain and behavior for mothers with OUD and BT. Building on our work on functional connectivity in the maternal brain for depression and parental intervention, we conducted longitudinal functional magnetic resonance imaging (fMRI) in humans to examine resting-state functional connectivity (rs-FC) between the periaqueductal gray (PAG) and hypothalamus + maternal bonding associations.
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