Abstract
BackgroundThis study aimed to explore the resting-state fMRI changes in Chinese boys with low functioning autism spectrum disorder (LFASD) and the correlation with clinical symptoms.MethodsThe current study acquired resting-state fMRI data from 15 Chinese boys with LFASD and 15 typically developing (TD) boys to examine the local brain activity using the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) indexes; the researchers also examined these measures and their possible relationships with clinical symptoms using the autism behavior checklist.ResultsResults indicated that boys with LFASD exhibited increased ReHo in the right precuneus and inferior parietal gyrus (IPG), increased ALFF in right middle temporal gyrus, angular gyrus and IPG. However, no correlation was found between the ALFF/ReHo score and clinical symptoms in the LFASD group.ConclusionsSome of the brain regions had ReHo/ALFF values that were higher in the boys with LFASD than the TD group and these differentiated brain areas in boys with LFASD were all on the right cerebrum, which supported ‘atypical rightward asymmetry’ in boys with LFASD.
Highlights
Autism spectrum disorders (ASDs) are increasingly prevalent neurodevelopmental disorders characterized by impaired social interaction and repetitive behaviors [1]
In the current research study, we aimed to explore the difference between the boys with low functioning autism spectrum disorder (LFASD) and typically developing (TD) using Reho and amplitude of low-frequency fluctuation (ALFF), and examined the correlation between regional homogeneity (ReHo)/ALFF and clinical symptoms
Demographic data Nineteen boys with LFASD participated in our study
Summary
Autism spectrum disorders (ASDs) are increasingly prevalent neurodevelopmental disorders characterized by impaired social interaction and repetitive behaviors [1]. Long distance under-connectivity and local over-connectivity in individuals with autism have been reported by many studies [2, 3]. Resting-state fMRI is a method of functional brain imaging that can be used to evaluate regional interactions that occur when a subject is not performing an explicit task [4]. Resting-state data obtained through the scans can be analyzed using a variety of methods. ReHo and ALFF are two methods widely used for characterizing local spontaneous activity of RS-fMRI data. This study aimed to explore the resting-state fMRI changes in Chinese boys with low functioning autism spectrum disorder (LFASD) and the correlation with clinical symptoms
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