Respuesta al tratamiento y características de los pacientes con pioderma gangrenoso atendidos en una institución de referencia en Antioquia, Colombia, entre 2015 y 2021

Abstract

IntroductionPyoderma gangrenosum (PG) is an autoinflammatory neutrophilic dermatosis that affects mainly in women, and it is associated with other autoimmune such as inflammatory bowel disease and rheumatoid arthritis. Data about its epidemiology in Latin America, and specifically in Colombia, is scarce. MethodologyA characterization of patients with PG through a cross-sectional study was conducted. The patients were attended in the dermatology service in a tertiary level institution, from January 2015 to December 2021. It included the registries of patients with the diagnosis and whose medical records had complete data about autoimmune comorbidity and laboratory. Results22 patients with PG were analyzed, it was found that the mean age of presentation was 50 years and mainly in women, the most common variant was ulcerative, and the most frequent location was the lower limbs. Half of the patients presenting as a single lesion and mostly with ulcerative lesion with undermined edges and less than 10 cm in size. A total of 22.7% of cases were related to autoimmune disease. Patients were managed with topical, systemic steroid and other systemic immunomodulators, with satisfactory response in 77.3% of them. ConclusionsFamily physicians and dermatologists should become familiar with this entity since it has an unpredictable evolution and prognosis. It is of great importance to recognize, diagnose and treat the disease properly and early.