Responsiveness of electrical nociceptive detection thresholds to capsaicin (8%)-induced changes in nociceptive processing.

Robert J Doll,Guido Van Amerongen,Justin L Hay,Jan R Buitenweg,Peter H Veltink,Geert J Groeneveld

doi:10.1007/s00221-016-4655-z

Robert J Doll, Guido Van Amerongen + Show 4 more

Open Access

https://doi.org/10.1007/s00221-016-4655-z

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Abstract

Pain disorders can be initiated and maintained by malfunctioning of one or several mechanisms underlying the nociceptive function. Psychophysical procedures allow the estimation of nociceptive detection thresholds using intra-epidermal electrical stimuli. By varying the temporal properties of electrical stimuli, various contributions of nociceptive processes to stimulus processing can be observed. To observe the responsiveness of nociceptive thresholds to changes in nociceptive function, a model of capsaicin-induced nerve defunctionalization was used. Its effect on nociceptive detections thresholds was investigated over a period of 84 days. A cutaneous capsaicin (8 %) patch was applied for 60 min to the upper leg of eight healthy human participants. Single- and double-pulse electrical stimuli were presented in a pseudo-random order using an intra-epidermal electrode. Stimuli and corresponding responses were recorded on both treated and untreated skin areas prior to capsaicin application and on days 2, 7, 28, and 84. Increases in electrical detection thresholds at the capsaicin area were observed on days 2 and 7 for single-pulse stimuli. Detection thresholds corresponding to double-pulse stimuli were increased on days 7 and 28, suggesting a delayed and longer lasting effect on double-pulse stimuli. In the present study, it was demonstrated that the responsiveness of detection thresholds to capsaicin application depends on the temporal properties of electrical stimuli. The observation of capsaicin-induced changes by estimation of detection thresholds revealed different time patterns of contributions of peripheral and central mechanisms to stimulus processing.

Highlights

Chronic pain disorders can be initiated and maintained by malfunctioning of one or several mechanisms underlying the nociceptive function (Mendell 2011; Sandkühler 2009; Woolf 2011)
It was demonstrated that the responsiveness of detection thresholds to capsaicin-induced changes in nociceptive processing depends on the temporal properties of electrical stimuli
The detection thresholds to single-pulse stimuli were increased on days 2 and 7 after capsaicin application, while the detection thresholds to double-pulse stimuli were increased on days 7 and 28

Summary

Introduction

Chronic pain disorders can be initiated and maintained by malfunctioning of one or several mechanisms underlying the nociceptive function (Mendell 2011; Sandkühler 2009; Woolf 2011). Several methodologies exist to quantify pain processing, such as psychophysical and neurophysiological assessment of sensory function, it remains difficult to detect specific malfunctioning mechanisms. This could hamper mechanism-based treatment of (potential) pain syndromes such as small fiber neuropathy (Devigili et al 2008), complex regional pain syndrome (Borchers and Gershwin 2014), or persistent post-surgical pain (Kehlet et al 2006). Quantitative sensory testing (QST) methods allow psychophysical assessments of sensory function (ArendtNielsen and Yarnitsky 2009) These methods include application of a broad range of stimulus types such as thermal, mechanical, or electrical and recording corresponding responses. Thermal and electrical stimuli can be used for preferential stimulation of nociceptive nerve fibers

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