Abstract
Cancer incidence is increasing progressively in recent years, and its wide distribution among younger generations raises even greater concerns. This caused an acceleration in the development of medicine by implementing modern methods for diagnosis, treatment, and therapy. In this context, polymer-functionalized magnetic nanomaterials evolved as helpful tools for both the medical and pharmacological fields. The present study reports the structural analysis and biocompatibility assessment of poly(tartaric acid) and its corresponding magnetic nanostructures. The current research aimed to elaborate a preliminary study on the responsiveness assessment of cell cultures exposed to these nanomaterials for future biomedical applications. Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) highlighted the successful attachment of the polyester on the magnetite surface and the preparation of the core-shell magnetic nanostructures. Biochemical experiments were performed in vitro on three types of human cell lines: normal keratinocytes, lung carcinoma, and skin melanoma. Viability, membrane integrity, and oxidative analyses performed on the obtained nanostructures proved a great inhibitory potential against cancer cell lines and little to no harmful effect against normal cell lines.
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