Abstract
BackgroundA responsive electrical stimulation pattern based on our recently developed novel seizure prediction method was designed to suppress the penicillin-induced epileptic seizures.MethodologySeizures were induced by Penicillin injection at rat cortex. A responsive electrical stimulation system was triggered prior to seizures predicted with phase synchronisation. Rats with induced seizures were stimulated by the electrical pulses at a responsive or 1 Hz periodic pattern of an open system. The effectiveness of stimulation on seizures suppression was assessed by measuring the average number and duration of seizures per hour.ResultsThe prediction algorithm reliably identified seizures in real time and triggered the responsive stimulation. This type of electrical stimulation dramatically suppressed seizure activity and the performance was better than the open stimulation system with fewer and shorter seizures.ConclusionsA responsive electrical stimulation system triggered by the phase synchronisation prediction is able to significantly suppress seizures.SignificanceResponsive electrical stimulation could achieve superior treatment performance and reduce power consumption and side effects.
Highlights
Treatment for epilepsy is still challenging in clinic
The prediction algorithm reliably identified seizures in real time and triggered the responsive stimulation. This type of electrical stimulation dramatically suppressed seizure activity and the performance was better than the open stimulation system with fewer and shorter seizures
A responsive electrical stimulation system triggered by the phase synchronisation prediction is able to significantly suppress seizures
Summary
Treatment for epilepsy is still challenging in clinic. Pharmacologic treatments for epilepsy are safe but the effectiveness is not satisfactory [1]. One third of patients respond unfavorably to any antiepileptic medication or experience intolerable medication-related side effects [2,3,4]. For these intractable patients, surgical resection is an alternative treatment. Electrical brain stimulation has become available for movement disorders, pain and psychiatric diseases [7]. It has been used for epilepsy treatment as well the performance is not as good as the treatment for movement disorders. A responsive electrical stimulation pattern based on our recently developed novel seizure prediction method was designed to suppress the penicillin-induced epileptic seizures
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