Abstract
The responses of liver and serum glutamate dehydrogenase (CDII; EC 1.4.1.2.), isocitrate dehydrogenase (ICDH; EC 1.1. 1.42) and the urea cycle enzyme, ornithine carbamoyltransferase (OCT; EC 2. 1.3.3) to dietary lima bean haemagglutinin (lectin) were assessed using a total of S4 growing rats. The GDH and ICDH activities in the liver were highly significantly (P < 0.001) elevated by dietary haemagglutinin. The activities correlated significantly (P < 0.01) with the haemagglutinin levels in a positive quadratic fashion as judged by their respective R2, coefficient of multiple determination of 0.91 and 0.95. Liver OCT activity was significantly (P < 0.05) depresseed but correlated poorly with haemagglutinin levels. Activities of the serum dehydrogenases were significantly (P < 0.05) altered by dietary haemagglutinin. Although serum OCT activity tended to increase, such increases were however not significant. Serum GDH and ICDH values correlated significantly (P < 01.05) with haemagglutinin levels with respective R2 values of 0.71 and 0.67. The veterinary implication is highlighted and some remedies suggested.
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