Abstract
Responses of strain DBAf/2 mice without the mammary tumor agent to oral administration of methylcholanthrene are reported. Mice of both sexes 2-4 months of age were given 9 weekly injections by stomach tube of 1 mg of methylcholanthrene dissolved in .2 cc of olive oil. Mammary gland tumors were induced in the females and leukemias chiefly mediastinal lymphosarcomas localized to the mediastinum were induced in both sexes. Microscopic sections from 54 of the mediastinal masses revealed 52 which were similar and were diagnosed as lymphocytic neoplasms apparently originating in the thymus. All showed the same type of neoplastic cell which had the characteristic features of malignant lymphocytes.
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