Abstract
The response of sensory nerve fibers to inflammation was studied in the pulp and periapex of 64 injured molars from 16 adult rats. Tissues were evaluated at 1, 5, 8, 11, 14, or 21 days after injury using immunocytochemistry for calcitonin gene-related peptide. The extent of surviving pulpal innervation was studied and the size of periapical lesions was measured. Persistence of nerve fibers in the pulp was found up to 14 days after injury, whereas periapical lesions were present as early as 5 days after injury. Extensive sprouting of the nerve fibers was found throughout the surviving pulp by 5 days after injury and persisted in later groups. Innervation of the periapical area had also increased by 5 days with additional sprouting at later times. The active role of calcitonin gene-related peptide fibers in neurogenic inflammation and dental pathosis is discussed as well as the clinical relevance of coexisting pulpal innervation and periapical lesions.
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