Abstract
We appreciate the questions raised and the interpretations offered by our colleagues and respond as follows. First, we provided data on the ratio of sarcolemmal to total glucose transporter (GLUT)-4 as an accepted and standard method for establishing insulin mediated GLUT-4 translocation. There was no difference in the total GLUT-4 protein expression between control and glucagon-like peptide (GLP)-1–treated groups. Therefore, the ratio reflects insulin-mediated translocation. This is consistent with the increase in Akt-phosphorylation at both the catalytic and regulatory subunits. The ratio of …
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