Response to Roles of Sex Steroid Hormones and Nitric Oxide in the Regulation of Sympathetic Nerve Activity in Women

Abstract

We thank Dr Tsuda1 for recognizing our work and bringing to light additional aspects of the complex effect of estrogen on sympathetic nerve activity and NO. Indeed, NO-synthase is well known to be upregulated by estrogen, and endothelial function (via flow-mediated dilation) is known to be improved during the high-estrogen phases of the menstrual cycle.2,3 We have recently shown that transdermal estrogen in young women improves …