Response to: ‘Relation between cartilage loss and pain in knee osteoarthritis’ by Wu et al and ‘Changes in synovitis and bone marrow lesions may not mediate the effect of cartilage loss on joint pain in osteoarthritis’ by Cashin et al

Abstract

Our paper1 was primarily focused on the small effect that preventing cartilage loss has on pain reduction. In an additional analysis, we noted that synovitis change mediated a small percentage...