Abstract
A response to and comment on Pre-referral rectal artesunate in severe malaria: a flawed trial, by Karim F Hirji and Zulfiqarali G Premji.
Highlights
A response to and comment on Pre-referral rectal artesunate in severe malaria: a flawed trial, by Karim F Hirji and Zulfiqarali G Premji
The study was planned to allow for differences in practice and malaria endemicity at the various study sites, making it possible to reach more general conclusions based on large numbers and variable conditions of practice
A data analysis plan agreed before unblinding defined the exclusion of patients who did not have malaria or had already received parenteral anti-malarial just before randomisation
Summary
A response to and comment on Pre-referral rectal artesunate in severe malaria: a flawed trial, by Karim F Hirji and Zulfiqarali G Premji. The design, execution and analysis reflected the two principal outcomes of death or permanent disability which were clearly defined.
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