Abstract
No abstract
Highlights
Rheumatoid arthritis (RA) is a complex polygenic disease characterized by progressive joint destruction
DNA samples from 122 Japanese Anti-citrullinated peptide antibody (ACPA)-negative RA patients were used for the study; 81.1% were female, 51.6% were rheumatoid factor (RF)-positive, and the mean age was 55 years
The genetic risk of joint damage associated with rs2240340 was assessed by multiple regression analysis adjusted for HLA-DRB1 shared-epitope alleles and RF that are thought to be associated with joint damage in patients with RA [4]
Summary
Rheumatoid arthritis (RA) is a complex polygenic disease characterized by progressive joint destruction. DNA samples from 122 Japanese ACPA-negative RA patients were used for the study; 81.1% were female, 51.6% were rheumatoid factor (RF)-positive, and the mean age was 55 years. Sharp/van der Heijde score of the hands at a 5-year disease duration, which represents joint damage, was scored and log-transformed as described elsewhere [4].
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