Abstract
Response: We appreciate Hsieh and Chen’s interest in our study. We agree that understanding the pathomechansim of the development of intraplaque hemorrhage (IPH) is of key importance that may help to develop therapeutic strategies to arrest or reverse the processes of atherosclerosis. Although no direct causal relationship between IPH and embolic stroke has been established, a number of studies have highlighted IPH as a marker of plaque rupture.1–3 The noninvasive detection of MR IPH will prove very useful for future in vivo pathophysiological studies. We also thank Tang and colleagues for their interest in our work and the opportunity to clarify their misunderstanding. It was our study aim to evaluate the clinical relevance of a previously described and histologically validated MRI surrogate marker of the unstable plaque.4 From a clinical practice perspective it is desirable to identify patients at high or low …
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